Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. Moore has been published in "Family Circle" magazine and the "Milwaukee Sentinel" newspaper, along with numerous other national and regional magazines, daily and weekly newspapers and corporate publications. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). MayoClinic.com: Grapefruit Juice -- Beware of Dangerous Medication Interactions, American Family Physician: Management of Grapefruit-Drug Interactions, Florida Citrus Mutual: Study -- No Adverse Effects Between Lipitor, Grapefruit Juice. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. The culprit: furanocoumarins, compounds found in grapefruits, that affects how your body processes certain statins (tangelos and Seville oranges are off-limits, too). This enzyme is essential for breaking down Lipitor and other statin drugs. In addition, patients should either refrain from the use of oat bran and pectin or, if concurrent use cannot be avoided, to separate the administration times by at least 2 to 4 hours. She specializes in writing about personal development, health, careers and personal finance. Lipitor also lowers cholesterol and triglyceride blood levels. Different foods have adverse interactions with different medications. Our team periodically reviews articles in order to ensure content quality. Patients should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Throwing up and I am on meds and have been drinking grapefruit juice? This can increase the risk of negative effects and lead to toxicity. On Foods to Avoid when on Statins. The website does not list other citrus fruits, such as blood oranges, as having a negative interaction with Lipitor. https://www.drugs.com/food-interactions/atorvastatin,lipitor.html. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. MANAGEMENT: Patients receiving therapy with atorvastatin should limit their consumption of grapefruit juice to no more than 1 liter per day. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). If you are experiencing serious medical symptoms, seek emergency treatment immediately. Research has shown that grapefruit disrupts the metabolism, or breakdown, of many medications, according to an article published in the August 15, 2006 issue of "American Family Physician.". Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. An interaction might increase or decrease the effectiveness or side effects of either substance. While Lipitor doesn't interact with blood oranges, it does interact with many over-the-counter supplements and medications, and a large number of prescription drugs. GENERALLY AVOID: Coadministration with grapefruit juice may increase the plasma concentrations of atorvastatin. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. Although statins are the most effective oral medications for lowering your cholesterol, other types of drugs also are available. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. She has a Bachelor of Science in psychology. For many years, doctors have recommended avoiding grapefruit while taking statins, but a study sponsored by the Florida Department of Citrus and published in the "British Journal of Clinical Pharmacology" in 2011 found only an insignificant interaction between grapefruit and Lipitor and no negative effects 3. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. Greater increases in Cmax (up to 71%) and/or AUC (up to 2.5 fold) have been reported with excessive consumption of grapefruit juice (>=750 mL to 1.2 liters per day). The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Available for Android and iOS devices. In particular, oranges and lemons are loaded with d-limonene, which gives these citrus fruits their pleasant scent. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. It is believed that the juice and pulp of grapefruit, pomelos and Seville oranges (not regular oranges) contain a chemical that inhibits the enzyme, so the statin doesn't get a chance to clear out making the dose circulating in the blood much higher and more potent then intended. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. Please check with the appropriate physician regarding health questions and concerns. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. GENERALLY AVOID: Coadministration with grapefruit juice may increase the plasma concentrations of atorvastatin. Dr. Savard says avoiding grapefruit juice is important as it can interfere with how the statin metabolizes in the body. Still looking for answers? Like other varieties of oranges, blood oranges are citrus fruits. Sometimes, taking a combination of cholesterol drugs can provide the same result with lower doses of statins. Oranges & Lemons Improve Cholesterol Numbers Naturally. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition.
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