(1998): 397-402, Bailey DG, Malcolm J, Arnold O, Spence JD "Grapefruit juice-drug interactions." Other drugs that have the same active ingredients (e.g. If you have an allergy to ezetimibe or any other part of Zetia (ezetimibe). Atorvastatin may cause liver problems and using it with substantial quantities of ethanol may increase that risk. Avoid drinking alcohol and smoking while you're on Zetia. Clin Pharmacokinet 47 Zocor (simvastatin)." Common interactions include amnesia among females and chest pain among males. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Most of it side effects are GI --indigestion and changes in bowel habits. They can include severe muscle pain and kidney damage, among other significant adverse reactions. You should limit the use of alcohol while being treated with these medications. Dosage of drugs is not considered in the study. Minimally clinically significant. There are 265 drug interactions with ezetimibe / simvastatin. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Mevacor (lovastatin)." (1998): 477-83. Drug Information on Zetia (ezetimibe) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Most likely your drugs were not approved in clinical trials based on patients like you. There are 3 alcohol/food/lifestyle interactions with atorvastatin / ezetimibe which include: Moderate Alcohol (Ethanol) ↔ atorvastatin. [See also DRUG INTERACTIONS] ZETIA had no significant effect on a series of probe drugs (caffeine, dextromethorphan, tolbutamide, and IV midazolam) known to be metabolized by cytochrome P450 (1A2, 2D6, 2C8/9 and 3A4) in a “cocktail” study of twelve healthy adult males. Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Zetia (ezetimibe) reduces the amount of cholesterol absorbed by the body. Clin Pharmacol Ther 63 (2008): 463-74, Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors." The phase IV trial will monitor drug safety outcomes that are personalized to your gender and age (0-99+). Important information. Available for Android and iOS devices. Moderate Drug Interaction. It is recommended that patients use the information presented as a part of a broader decision-making process. Zetia (ezetimibe): Zetia (ezetimibe) prevents GI absorption of cholesterol. The interaction has also been reported with lovastatin, which has a similar metabolic profile to simvastatin. There are no known interactions between Zetia and alcohol. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness while taking these medications, especially if these symptoms are accompanied by fever or dark colored urine. Moderately clinically significant. ADJUST DOSING INTERVAL: Fibres such as oat bran and pectin may diminish the pharmacologic effects of HMG-CoA reductase inhibitors by interfering with their absorption from the gastrointestinal tract. Usually avoid combinations; use it only under special circumstances. We comply with the HONcode standard for trustworthy health information -, Drug class: antihyperlipidemic combinations. Drug interactions are reported among people who take Zetia and Alcohol. When a single 60 mg dose of simvastatin was coadministered with 200 mL of double-strength grapefruit juice three times a day, simvastatin systemic exposure (AUC) increased by 16-fold and simvastatin acid AUC increased by 7-fold. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. (1998): 101-10. * Approximation only. Highly clinically significant. Lancet 338 13 people who take Zetia and Alcohol together, and have interactions are studied. Simvastatin may cause liver problems and using it with substantial quantities of ethanol may increase that risk. In some cases, rhabdomyolysis can cause kidney damage and even death. Common interactions include amnesia among females and chest pain among males. "Product Information. MANAGEMENT: Patients receiving therapy with lovastatin, simvastatin, or red yeast rice (which contains lovastatin) should be advised to avoid the consumption of grapefruit and grapefruit juice. By design, clinical trials use only a small and selected set of people, and are conducted in a highly controlled environment. Using ezetimibe together with simvastatin can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Alcohol has active ingredients of alcohol. It is based on ezetimibe and alcohol (the active ingredients of Zetia and Alcohol, respectively), and Zetia and Alcohol (the brand names). All rights reserved. (1991): 706, Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." What do I need to tell my doctor BEFORE I take Zetia? If you are allergic to Zetia (ezetimibe); any part of Zetia (ezetimibe); or any other drugs, foods, or substances. Do not stop using any medications without first talking to your doctor. Select one or more newsletters to continue. Clin Pharmacol Ther 64 It is important to tell your doctor about all other medications you use, including vitamins and herbs. eHealthMe is studying from 43,144 Zetia users now. It's free, simple and anonymous. © 2020 eHealthMe.com. Zetia and Alcohol drug interactions by gender *: Zetia and Alcohol drug interactions by age *: Personalize this study to your gender and age (0-99+), and then find any serious effects. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. The study is created by eHealthMe based on reports of 13 people who take Zetia and Alcohol from the FDA, and is updated regularly. A study for a 27 year old woman who takes Depo-provera, Klonopin, Remeron, A study for a 57 year old woman who takes Flexeril, Mobic, Mucinex, Synthroid, A study for a 33 year old woman who takes Saw Palmetto, A study for a 14 year old boy who takes Irinotecan Hydrochloride, A study for a 44 year old woman who takes Grifulvin V, Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma), Faecal incontinence (a lack of control over passing stool), Renal failure acute (rapid kidney dysfunction), Ascites (accumulation of fluid in the abdominal cavity), Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm), Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation), Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes), Metastases to liver (cancer spreads to liver), Bradycardia (abnormally slow heart action), Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body), Nausea (feeling of having an urge to vomit), Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively), Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain), Hallucination (an experience involving the perception of something not present), Hypertriglyceridaemia (excess of triglycerides in the blood), Pancreatitis acute (sudden inflammation of pancreas), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down), Rhinorrhoea (watery mucus discharge from the nose), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies), Disorientation (disability in which the senses of time, direction, and recognition of people and places), Flushing (the warm, red condition of human skin).
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